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3 Factors other than ageing that can lower glutathione levels: Chronic stress Smoking and alcohol use Poor and inadequate nutrition Prolonged exposure to environmental toxins Chronic diseases Clinical studies have shown that glutathione deficiency is the primary cause of oxidative stress in older individuals, and that this can be corrected by dietary cysteine and glycine supplementation

doi: 10.1016/j.exer.2020.108255 357 MoosWHFallerDVGlavasIPHarppDNKamperiNKanaraIet al